Cellular Immunoisolation for Islet Transplantation by a Novel Dual Porosity Electrospun Membrane
نویسندگان
چکیده
منابع مشابه
Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport
Problems associated with islet transplantation for Type 1 Diabetes (T1D) such as shortage of donor cells, use of immunosuppressive drugs remain as major challenges. Immune isolation using encapsulation may circumvent the use of immunosuppressants and prolong the longevity of transplanted islets. The encapsulating membrane must block the passage of host's immune components while providing suffic...
متن کاملIntroducing a New Experimental Islet Transplantation Model using Biomimetic Hydrogel and a Simple High Yield Islet Isolation Technique
Background: Islet transplantation could be an ideal alternative treatment to insulin therapy for type 1 diabetes Mellitus (T1DM). This clinical and experimental field requires a model that covers problems such as requiring a large number of functional and viable islets, the optimal transplantation site, and the prevention of islet dispersion. Hence, the methods of choice for isolation of functi...
متن کاملدرمان دیابت القاء شده با استرپتوزوتوسین به وسیله قرنطینه ایمنی سلولهای جزایر لانگرهانس از طریق پیوند درموشهای صحرایی نر
Introduction & Objective: Insulin injection is the main way to combat against insulin-dependent diabetes mellitus effects. Today in some laboratories in the world, the investigators are trying to find some treatments for this disease with insulin-secreting pancreatic islet cells transplantation. Encapsulation of pancreatic islet cells allows for transplantation in the absence of immunosuppressi...
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ژورنال
عنوان ژورنال: Transplantation Proceedings
سال: 2011
ISSN: 0041-1345
DOI: 10.1016/j.transproceed.2011.10.031